.23, P = 0.001) and (t(177) = – 3.20, P = 0.002), respectively. All the participants reacted faster to ordinary than to extraordinary roles for both acceptances and rejections (F(1, 163) = 5.49, P = 0.020). Globally, accepting roles took longer than rejecting them (F(1, 163) = 4.37, P = 0.038). The mixed-model ANOVA showed absolutely no effect of SPQ scores on the reaction times (F(1, 163) = 0.024, P = 0.876). There was an ordinariness ?favorability ?SPQ interaction (F(1, 163) = 4.12, P = 0.044), but post hoc analyses using independent samples t-tests revealed no difference between the participants with high- and those with low-SPQ scores for any combinations. DISCUSSION The drive to perform extraordinary social roles was quantified in healthy subjects to see whether it predicts schizophrenia-like symptoms, particularly subclinical disorganization. As expected, the greater the number of extraordinary roles participants were willing to engage in, the higher their schizotypy scores as measured by the SPQ (Figures 1b and d). The multiple regression revealed that the percentages of acceptances of the roles that differ the most from ordinary favorable roles, that is, the extraordinary unfavorable roles, were the ones that best predicted the clinical scores. This supports the idea that the drive for performing roles that are the most difficult to reconcile with those that most people have to perform in everyday life may engender the subclinical disorganization symptoms measured by the SPQnpj AZD0156MedChemExpress AZD0156 Schizophrenia (2016) 16035 Extraordinary unfavorable roles 9.34E – 09 0.00003 7.43E – 07 8.63E – 08 0.039 0.0003 0.00003 0.00006 0.078 0.040 0.097 0.055 0.061 – 0.016 0.024 0.036 Total SPQ Interpersonal Delusion-like ideation Disorganization Total PDI PDI distress PDI preoccupation PDI conviction 0.145 0.113 0.123 0.127 0.060 0.056 0.098 0.100 0.044 0.117 0.088 0.079 0.502 0.531 0.274 0.265 0.401 0.287 0.368 0.370 0.209 0.324 0.402 0.386 7.17E – 09 0.00005 1.45E – 07 1.16E – 07 0.019 0.00002 3.16E – 06 7.86E -06 0.251 0.165 0.256 0.212 0.145 0.166 0.245 0.246 0.0004 0.022 0.0003 0.003 0.106 0.063 0.006 0.006 0.324 0.256 0.259 0.308 0.138 0.243 0.289 0.274 4.26E – 06 0.0003 0.0003 0.00001 0.124 0.006 0.001 0.002 0.284 0.584 0.178 0.450 0.497 0.858 0.786 0.Abbreviations: PDI, Peters et al. Delusion Inventory; SDS, social desirability scale; SPQ, schizotypal personality questionnaire. N = 195 for the SPQ and its three factors and N = 128 for the PDI and its three subscales. Values in bold are statistically significant P values (Po 0.05).P r P r P r P r P r P r P r P rPearson’s correlation coefficients between the percentages of acceptance for each social role and the SPQ and PDI scores when controlling for age, education, and SDSExtraordinary favorable rolesOrdinary unfavorable rolesPublished in partnership with the Schizophrenia International Research SocietyTable 2.Clinical scoresOrdinary rolesExtraordinary rolesFavorable rolesUnfavorable rolesOrdinary favorable roles0.194 0.174 0.127 0.186 0.069 0.128 0.160 0.0.007 0.016 0.079 0.016 0.442 0.155 0.074 0.0.359 0.248 0.344 0.320 0.196 0.291 0.382 0.3.06E – 07 0.001 9.35E – 07 5.74E – 06 0.028 0.001 0.00001 0.0.399 0.297 0.347 0.374 0.184 0.314 0.364 0.Extraordinary roles and schizotypy AL Fernandez-Cruz et alFigure 1. (a ) Percentages of roles accepted in each category combination according to SPQ scores. Each small circle represents a alpha-Amanitin cost participant (n = 203). Its `x’ coordinate is his/her SPQ score and the `y..23, P = 0.001) and (t(177) = – 3.20, P = 0.002), respectively. All the participants reacted faster to ordinary than to extraordinary roles for both acceptances and rejections (F(1, 163) = 5.49, P = 0.020). Globally, accepting roles took longer than rejecting them (F(1, 163) = 4.37, P = 0.038). The mixed-model ANOVA showed absolutely no effect of SPQ scores on the reaction times (F(1, 163) = 0.024, P = 0.876). There was an ordinariness ?favorability ?SPQ interaction (F(1, 163) = 4.12, P = 0.044), but post hoc analyses using independent samples t-tests revealed no difference between the participants with high- and those with low-SPQ scores for any combinations. DISCUSSION The drive to perform extraordinary social roles was quantified in healthy subjects to see whether it predicts schizophrenia-like symptoms, particularly subclinical disorganization. As expected, the greater the number of extraordinary roles participants were willing to engage in, the higher their schizotypy scores as measured by the SPQ (Figures 1b and d). The multiple regression revealed that the percentages of acceptances of the roles that differ the most from ordinary favorable roles, that is, the extraordinary unfavorable roles, were the ones that best predicted the clinical scores. This supports the idea that the drive for performing roles that are the most difficult to reconcile with those that most people have to perform in everyday life may engender the subclinical disorganization symptoms measured by the SPQnpj Schizophrenia (2016) 16035 Extraordinary unfavorable roles 9.34E – 09 0.00003 7.43E – 07 8.63E – 08 0.039 0.0003 0.00003 0.00006 0.078 0.040 0.097 0.055 0.061 – 0.016 0.024 0.036 Total SPQ Interpersonal Delusion-like ideation Disorganization Total PDI PDI distress PDI preoccupation PDI conviction 0.145 0.113 0.123 0.127 0.060 0.056 0.098 0.100 0.044 0.117 0.088 0.079 0.502 0.531 0.274 0.265 0.401 0.287 0.368 0.370 0.209 0.324 0.402 0.386 7.17E – 09 0.00005 1.45E – 07 1.16E – 07 0.019 0.00002 3.16E – 06 7.86E -06 0.251 0.165 0.256 0.212 0.145 0.166 0.245 0.246 0.0004 0.022 0.0003 0.003 0.106 0.063 0.006 0.006 0.324 0.256 0.259 0.308 0.138 0.243 0.289 0.274 4.26E – 06 0.0003 0.0003 0.00001 0.124 0.006 0.001 0.002 0.284 0.584 0.178 0.450 0.497 0.858 0.786 0.Abbreviations: PDI, Peters et al. Delusion Inventory; SDS, social desirability scale; SPQ, schizotypal personality questionnaire. N = 195 for the SPQ and its three factors and N = 128 for the PDI and its three subscales. Values in bold are statistically significant P values (Po 0.05).P r P r P r P r P r P r P r P rPearson’s correlation coefficients between the percentages of acceptance for each social role and the SPQ and PDI scores when controlling for age, education, and SDSExtraordinary favorable rolesOrdinary unfavorable rolesPublished in partnership with the Schizophrenia International Research SocietyTable 2.Clinical scoresOrdinary rolesExtraordinary rolesFavorable rolesUnfavorable rolesOrdinary favorable roles0.194 0.174 0.127 0.186 0.069 0.128 0.160 0.0.007 0.016 0.079 0.016 0.442 0.155 0.074 0.0.359 0.248 0.344 0.320 0.196 0.291 0.382 0.3.06E – 07 0.001 9.35E – 07 5.74E – 06 0.028 0.001 0.00001 0.0.399 0.297 0.347 0.374 0.184 0.314 0.364 0.Extraordinary roles and schizotypy AL Fernandez-Cruz et alFigure 1. (a ) Percentages of roles accepted in each category combination according to SPQ scores. Each small circle represents a participant (n = 203). Its `x’ coordinate is his/her SPQ score and the `y.
