Ables as percentages. Results We included 67 patients, 57 males. The mean age
Ables as percentages. Results We included 67 patients, 57 males. The mean age was 38.02 ?17.49 years. The mean APACHE II score was 18.32 ?12.21. A total of 27 patients (40.29 ) developed 38 nosocomial infections (18 EO and 20 LO): 27 pneumonias (15 EO and 12 LO; seven MSSA, one MRSA, six Pseudomonas aeruginosa, four Hemophillus influenzae), six urinary tract infections (one EO and five LO; three CNS), two primary bacteremias (one EO and one LO; one CNS and one Acinetobacter), one catheter-related bacteremia (one LO; one Enterobacter), one ventriculitis (one EO; one CNS) and one wound surgical infection (one LO; one Pseudomonas aeruginosa). The microorganisms responsible for nosocomial infections were the following: eight MSSA, one MRSA, seven P. aeruginosa, five CNS, five H. influenzae and 12 others. Death occurred in 14 patients (20.89 ). Conclusions In our series, 40 of patients developed some infection. Two-thirds of nosocomial infections had a respiratory origin. The most frequent microorganisms were MSSA and P. aeruginosa. One-quarter of patients died.of a total of 1380 German hospitals with 2075 ICUs was obtained, forming five strata according to hospital size: strata 1? comprised all non-university hospitals with <200, 201?00, 401?00, and >600 beds, respectively, and stratum 5 comprised all PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27797473 university hospitals. Visits by experienced ICU physicians from SepNet’s 17 regional study centers were randomly distributed over a 1-year period to allow for seasonal variations. ICU directors were asked whether they used the sepsis criteria or not and marked either `always’, `frequently’, `sometimes’, `rarely’ or `never’ for their use of sepsis markers. Results PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27107493 Essential for diagnosis were: clinical criteria according to individual experience (96.5 ), positive blood culture (81.5 ), ACCP/SCCM Consensus Conference Criteria (56.6 ). In total 37.9 stated never using Gram-stains of respiratory specimens, and in 13.2 of these ICUs the laboratory turn around for first blood culture results was >24 hours. Of ICU directors, 90.5 stated using laboratory markers for sepsis diagnosis. The absolute leucocyte count was used in 92.7 (`always’); the differential leucocyte count, however, was used only in 47.8 (`always’). Creactive protein was the most preferred biochemical marker (`always’: 90.1 ), compared with procalcitonin (`always’: 13.9, `frequently’: 9.5, `sometimes’: 15.2 ), IL-6 (3.7, 4.2, 5.9 ) and lipopolysaccharide-binding protein levels (2.4, 2.0, 3.7 ). Conclusions The acceptance of the ACCP/SCCM criteria is low in Germany, similar to results from US and European surveys. For the diagnosis of sepsis, ICU physicians seem to rely more on their personal experience rather than on expert recommendations of standardized criteria. Procalcitonin levels are used by one-third of ICU physicians in addition to conventional laboratory markers and clinical signs of sepsis. Acknowledgments This study was supported by the Federal Ministry of Education and Research (BMBF) grant number 01 KI 0106 and Lilly Deutschland, GmbH.P121 Changing patterns of microbial resistance in an Indian cancer hospital ICUS Myatra, J Divatia, P Mehta, S Pai, R RO5186582 custom synthesis Kelkar, S Biswas, R Sareen Tata Memorial Hospital, Mumbai, India Critical Care 2006, 10(Suppl 1):P121 (doi:10.1186/cc4468) Aim To analyse the pattern of microbial isolates and antibiotic sensitivity with time, changing antibiotic prescription and improved infection control. Methods A 550-bed tertiary referral cancer cen.
