Upper regular level of two.two mmol/l; cum-lactate), and total cumulative SOFA score (cumSOFA) were calculated and associated with ICU LOS and final hospital survival. Values will be the median (interquartile range). Results Observations in 1,711 ICU admissions had been analyzed, age was 69 (57?7) years, cum-lactate was 420 (94?19 min mol/l) and cum-SOFA was 11 (four?eight). Cum-SOFA was greater in sufferers with hyperlactatemia (cum-lactate > 0) throughout the ICU stay (n = 782; 24 (7?1)) than in these with no (five (three?0); P < 0.001). Cum-SOFA correlated with cum-lactate and with ICU LOS, and cum-lactate correlated with ICU LOS (all P < 0.001). In patients who died in the hospital (n = 329), cum-lactate (1,180 (203?,427) min mol/l) and cum-SOFA (30 (10?5)) were higher than in hospital survivors (n = 1,382; 298 (73?,154) min mol/l, and 22 (5?7); both P < 0.001). In emergency admissions, cum-lactate (484 (113?,031)) and cum-SOFA (27 (8?8)) were higher than in planned admissions (131 (37?54)) and (4 (3?8); both P < 0.001), respectively. Conclusion In ICU patients, the cumulative area under the lactate curve correlates with the ICU LOS, cumulative SOFA score, and inhospital mortality. The prognostic value PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20799915 of cum-lactate needs prospective evaluation.P465 Sequential Organ Failure Assessment score trends and sepsis survival inside a Brazilian university hospital intensive care unitD Moreira Lima, B Ferreira Cordeiro de Almeida, R Cordioli, E Tadeu Azevedo Moura, I Schimdtbauer, A Nassar, F Maria Queiroz Silva, R Zigaib, D Forte, F Giannini, J BBT594 site Coelho, M Park Hospital das Cl icas FMUSP, S Paulo, Brazil Important Care 2007, 11(Suppl two):P465 (doi: 10.1186/cc5625) Introduction Sepsis is associated with progressive organ failure. We sought to describe Sequential Organ Failure Assessment (SOFA) score everyday trends in septic sufferers and tried to correlate those trends with survival. Methods Individuals with extreme sepsis or septic shock admitted for no less than 5 days in a seven-bed medicosurgical ICU of a Brazilian university hospital had been studied. The each day SOFA score for each and every patient was calculated throughout the first five days of admission. Relevant data had been prospectively acquired from March 2003 to May possibly 2006 and also the latter retrieved from a electronic database. ICU survivors have been compared with nonsurvivors using the Mann hitney U test. Day-to-day changes were verified within each and every group working with Friedman’s test. P 0.01 was elected because the significance limit. Medians and interquartile ranges (IQRs) had been applied to describe the sample.SCritical CareMarch 2007 Vol 11 Suppl27th International Symposium on Intensive Care and Emergency MedicineP467 Sequential Organ Failure Assessment score and procalcitonin serum concentrations in sufferers with systolic heart failure early after cardiac surgeryV Maravic-Stojkovic1, T Spasic1, M Jovic1, M Borzanovic1, B Djukanovic1, D Brunner2 1Dedinje Cardiovascular Institute, Belgrade, Serbia; 2Interlight, Lozana, Swaziland Critical Care 2007, 11(Suppl 2):P467 (doi: 10.1186/cc5627) Introduction Previously we investigated the clinical course of individuals with fantastic left ventricle ejection fraction (EF) by assessing the Sequential Organ Failure Assessment (SOFA) score and procalcitonin (PCT) level early immediately after cardiac surgery. In this study we included patients with systolic heart failure (HF), prospectively collecting data: B-type natriuretic peptide (BNP), PCT, and SOFA score. Methods Two hundred and seventy-five patients (subjected to coronary artery bypass grafting, valve.
