Eonine-protein kinase mTOR Muscarinic acetylcholine receptor M5 5-hydroxytryptamine receptor 2C Sodium-dependent
Eonine-protein kinase mTOR Muscarinic acetylcholine receptor M5 5-hydroxytryptamine receptor 2C mTOR Modulator MedChemExpress Sodium-dependent dopamine transporter C-reactive protein Apolipoprotein E Superoxide dismutase [Cu-Zn] Amine oxidase [flavin-containing] A Amine oxidase [flavin-containing] B Nitric oxide synthase, brain Mineralocorticoid receptor Sodium-dependent serotonin transporter Neuronal acetylcholine receptor subunit alpha-2 Collagen alpha-1(I) chain Cytochrome P450 2B6 D(1A) dopamine receptor Gamma-aminobutyric acid receptor subunit alpha-1 Glutamate receptor 2 5-hydroxytryptamine receptor 3A Sodium-dependent noradrenaline transporterUniProt ID P05019 P28223 P42345 P08912 P28335 Q01959 P02741 P02649 P00441 P21397 P27338 P29475 P08235 P31645 Q15822 P02452 P20813 P21728 P14867 P42262 P46098 P(a)(b)Figure three: PPI network of CCHP in treating depression. (a) PPI network constructed by STRING. (b) PPI network constructed by Cytoscape. Nodes represent targets, and edges stand for the interactions among the targets. In Figure 3(b), with a rise in the degrees, the colors of the nodes adjust from yellow to red, as well as the sizes in the nodes raise.We obtained compounds and corresponding targets from the TCMSP and STITCH databases. Sitosterol was a frequent compound in Cyperi Rhizoma and Chuanxiong Rhizoma. Quercetin, a flavonoid, is present in a lot of plants and exerts antidepressant effects by regulating the signaling connected to BDNF [51, 52], alleviating oxidative tension and neuroinflammation [53], and inhibiting astrocyte reactivation [54]. Similarly, luteolin can be a flavonoid with various biological properties [55]. e mechanisms underlying the antidepressant-like effect of luteolin may possibly include things like the inhibition of endoplasmic reticulum stress [55, 56] andthe regulation of monoaminergic and cholinergic functions [57]. e herb-compound-target network (Figure two) showed that the relationships involving the compounds and their corresponding targets had been complicated. Quercetin, luteolin, kaempferol, beta-sitosterol, and isorhamnetin had larger degrees than other compounds, and they have been core compounds within the network. A single compound can act on numerous targets, and a lot of compounds could share a popular target. erefore, we are able to infer that many compounds of CCHP may perhaps act on depression by way of multiple targets.response to drug good regulation of nitric oxide biosynthetic approach constructive regulation of transcription from RNA polymerase II promoter locomotory behavior response to heat constructive regulation of sequence-specific DNA binding transcription factor activity optimistic regulation of gene expression aging good regulation of ERK1 and ERK2 cascade constructive regulation of transcription, DNA-templated negative regulation of cell proliferation optimistic regulation of cell proliferation chemical synaptic transmission adverse regulation of apoptotic process inflammatory response signal transduction 0 5 Count 10Evidence-Based Complementary and Alternative Medicineneuronal cell physique integral element of plasma membrane plasma membrane extracellular area extracellular space membrane ra dendrite cytoplasm protein complicated postsynapse neuron projection perikaryon mitochondrion dendrite caveola cytoplasm axon 0 five 10 Count-log10 (β adrenergic receptor Agonist web PValue) 12.five ten.0 7.five 5.-log10 (PValue) 4Term(a)drug binding identical protein binding dopamine binding cytokine activity protein phosphatase 2A binding steroid binding protein homodimerization activity 1-(4-iodo-2,5-dimethoxyphenyl) propan-2-amin.
