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Hyperlipidemia is usually a disease of lipid metabolism featured by elevated total cholesterol (TC), total triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) and lowered high-density lipoprotein cholesterol (HDL-C) in the peripheral blood. In recent years, the incidence of hyperlipidemia continues to rise on account of decreased physical activities and elevated consumption of speedy foods higher in calorie and low in fiber [1]. And existing research DP Inhibitor Gene ID reveal that hyperlipidemia is usually a key danger element for cardiovascular diseases [2]. Thus, appropriate remedy of hyperlipidemia is of terrific significance. Clinically, its mainstay therapies include things like fibrates, statins, niacin, resins, and other lipid-lowering drugs [3]. Nonetheless, they may associate with treatmentresistance and intolerance and bring about a lot of adverse effects, such as gastrointestinal symptoms, myalgia, and respiratory infections [4]. Therefore, it can be necessary to research and create extra therapeutic possibilities for hyperlipidemia. The dry rhizome and root of Polygonum cuspidatum Sieb. et Zucc (Pc) can dispel dampness, do away with jaundice, clear heat, detoxification, dispel blood stasis, relieve pain, arrest cough, and resolve phlegm [5]. It consists of several different chemical compounds and has been extensively made use of as a Chinese medicinal material to t