Ificant except for the connection in between GLP-1 and HOMA- within the overweight/obese group (r = 0.300, P = 0.053).Wadden et al. Nutrition Metabolism 2013, ten:33 http://www.nutritionandmetabolism/content/10/1/Page 4 ofTable 1 Physical and biochemical traits of subjects at baseline and in response to 7-days of overfeedingEntire cohort (n = 72) Day 1 Age Height (cm) Weight (kg)b BMI (kg/m2)b Percent body fat % trunk fat Percent android fatb Percent gynoid fat Total cholesterol (mmol/L)b HDL cholesterol (mmol/L)b Total cholesterol:HDLc ratiob LDL cholesterol (mmol/L) Triacylglycerols (mmol/L)b Glucose (mmol/L) Insulin (pmol/L)b HOMA-IRb HOMA-b Serum GLP-1 (pmol/L)aa,bDay 8 N/A N/A 83.13 1.87 25.96 0.58 22.69 1.00 25.52 1.10 29.44 1.35 27.50 0.99 four.74 0.ten 1.41 0.03 three.47 0.10 2.75 0.08 1.44 0.16 5.11 0.06 86.84 7.78 2.92 0.p-value Modify () from baseline Average % transform from baseline ( ) 0.001 0.001 0.051 0.088 0.001 0.221 0.007 0.001 0.020 0.639 0.005 0.905 0.001 0.001 0.001 0.001 N/A N/A two.21 0.16 0.69 0.05 0.28 0.14 0.38 0.21 0.80 0.21 0.23 0.19 0.23 0.08 0.ten 0.02 -0.ten 0.04 0.03 0.06 0.35 0.15 0.01 0.07 18.29 6.98 0.54 0.29 43.80 9.30 five.55 1.57 N/A N/A 2.74 0.20 two.74 0.20 2.65 0.87 3.25 1.10 four.77 1.37 1.80 0.89 6.33 1.88 9.08 1.88 -2.11 1.12 2.88 2.17 44.74 21.54 0.75 1.31 55.02 9.53 59.71 10.77 50.60 eight.01 24.ten 5.23.11 0.37 179.18 0.72 80.92 1.81 25.27 0.56 22.41 1.05 25.15 1.17 28.64 1.38 27.27 1.03 4.50 0.ten 1.31 0.03 three.58 0.10 2.72 0.08 1.08 0.06 five.10 0.06 68.54 eight.27 two.38 0.b114.57 8.85 158.38 12.38 36.84 three.16 42.39 three.Values are imply SE. Homeostasis model assessment of insulin resistance (HOMA-IR) and of B cell function (HOMA-); GLP-1, Glucagon-like Peptide-1; N/A, not applicable. b Important difference present between pre- and post- overfeeding (paired t-test; SPSS 19.0).Table two Spearman correlations of baseline variables related to baseline fasting serum GLP-1 concentrationAll Subjects (n = 72) r Weight (kg) BMI (kg/m2) % physique fat Percent trunk fat % android fat % gynoid fat Total cholesterol HDL cholesterol Total cholesterol:HDLc ratio LDL cholesterol Triacylglycerols Glucose Insulin HOMA-IR HOMA-aa,bNormal weight (n = 30) r -0.197 -0.218 -0.027 -0.059 -0.075 -0.021 0.265 0.141 0.182 0.286 0.232 0.039 0.001 0.005 -0.074 P NS NS NS NS NS NS NS NS NS NS NS NS NS NS NSOverweight+Obese (n = 42) r 0.175 0.117 0.186 0.238 0.216 0.328 -0.037 -0.582 0.489 -0.065 0.526 0.191 0.394 0.375 0.353 P NS NS NS NS NS 0.036 NS 0.001 0.001 NS 0.001 NS 0.010 0.014 0.P NS NS NS NS NS NS NS 0.002 0.001 NS 0.001 NS NS NS NS0.052 -0.006 0.086 0.098 0.079 0.141 0.103 -0.357 0.383 0.Streptonigrin supplier 077 0.Brassicasterol HSV 412 0.157 0.216 0.207 0.P0.PMID:23381626 05 (IBM SPSS Statistics 19). b Homeostasis model assessment of insulin resistance (HOMA-IR) and of cell function (HOMA-); NS, non-significant. Subjects had been classifed based on adiposity suggestions by Bray as regular weight (80.9 ), overweight (215.9 ), or obese (26 ).Wadden et al. Nutrition Metabolism 2013, ten:33 http://www.nutritionandmetabolism/content/10/1/Page five ofCorrelations amongst baseline GLP-1 with % alter in physique composition and markers of lipid/glucose metabolismCorrelations amongst % adjust in GLP-1 with baseline body composition and lipid/glucose metabolism variablesThe correlative data in between fasting baseline GLP-1 concentration and percent adjustments inside the markers of adiposity, and lipid and glucose metabolism had been also observed. Inside the whole cohort, no relationships.
