E, et al. (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery towards the membrane. Dev Cell 7(6):85569. 12. Kasahara K, et al. (2007) Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, involving the plasma membrane and late endosomes/lysosomes. Exp Cell Res 313(12):2651666. 13. Sato I, et al. (2009) Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation inside the SH4 domain. J Cell Sci 122(Pt 7):96575. 14. Sandilands E, Brunton VG, Frame MC (2007) The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci 120(Pt 15):2555564. 15. Takeda H, et al. (2010) Comparative analysis of human SRC-family kinase substrate specificity in vitro. J Proteome Res 9(11):5982993. 16. Shah K, Shokat KM (2002) A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem Biol 9(1):357. 17. Brown MT, Cooper JA (1996) Regulation, substrates and functions of Src. Biochim Biophys Acta 1287(2-3):12149. 18. Thomas SM, Soriano P, Imamoto A (1995) Distinct and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature 376(6537):26771. 19. Karginov AV, Ding F, Kota P, Dokholyan NV, Hahn KM (2010) Engineered allosteric activation of kinases in living cells. Nat Biotechnol 28(7):74347. 20. Karginov AV, Hahn KM (2011) Allosteric activation of kinases: Style and application of RapR kinases. Current Protocols in Cell Biology (Wiley, New York) Chap 14, unit 13. 21. Roskoski R, Jr (2004) Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun 324(four):1155164. 22. Karginov AV, et al. (2014) Dissecting motility signaling by way of activation of distinct Src-effector complexes. Nat Chem Biol ten(4):28690. 23. Dagliyan O, et al. (2013) Rational style of a ligand-controlled protein conformational switch. Proc Natl Acad Sci USA 110(17):6800804. 24. Yamanashi Y, et al. (1989) Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc Natl Acad Sci USA 86(17):6538542.25. Frame MC (2002) Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602(two):11430. 26. Summy JM, Gallick GE (2003) Src family members kinases in tumor progression and metastasis. Cancer Metastasis Rev 22(four):33758. 27. Chen ZY, et al. (2010) Roles of Fyn in pancreatic cancer metastasis. J Gastroenterol Hepatol 25(two):29301. 28. Koch CA, Anderson D, Moran MF, Ellis C, Pawson T (1991) SH2 and SH3 domains: Components that control interactions of cytoplasmic signaling proteins.Crystal Violet Bacterial Science 252(5006):66874.L-(+)-Arabinose Purity 29.PMID:23357584 Songyang Z, Cantley LC (1995) Recognition and specificity in protein tyrosine kinasemediated signalling. Trends Biochem Sci 20(11):47075. 30. Weng Z, et al. (1994) Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol 14(7):4509521. 31. Summy JM, Guappone AC, Sudol M, Flynn DC (2000) The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes. Oncogene 19(1):15560. 32. Pulvirenti T, et al. (2008) A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway. Nat Cell Biol 10(eight):91222. 33. Alland L, Peseckis SM, Atherton RE, Berthiaume L, Resh MD (1994) Dual myr.