Recombinant Human CD59 Protein, GST-Tagged

Specification :
| Description : This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 40.6 kDa | AA Sequence : MGIQGGSVLFGLLLVLAVFCHSGHS LQCYNCPNPTADCKTAVNCSSDFDA CLITKAGLQVYNKCWKFEHCNFNDV TTRLRENELTYYCCKKDLCNFNEQL ENGGTSLSEKTVLLLVTPFLAAAWS LHP | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.