Share this post on:

Name :
Recombinant Human CD86 Protein, C-His-tagged

Specification :
| Description : CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation. CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions. Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity. | Source : E. coli | Species : Human | Tag : C-His | Molecular Mass : ~25 kDa | AA Sequence : APLKIQAYFNETADLPCQFANSQNQ SLSELVVFWQDQENLVLNEVYLGKE KFDSVHSKYMGRTSFDSDSWTLRLH NLQIKDKGLYQCIIHHKKPTGMIRI HQMNSELSVLANFSQPEIVPISNIT ENVYINLTCSSIHGYPEPKKMSVLL RTKNSTIEYDGVMQKSQDNVTELYD VSISLSVSFPDVTSNMTIFCILETD KTRLLSSPFSIELEDPQPPPDHIP | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4

Gene Information :
| Gene Name : CD86 CD86 molecule [ Homo sapiens (human) ] | Official Symbol : CD86 | Synonyms : CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413; | Gene ID : 942 | mRNA Refseq : NM_001206924 | Protein Refseq : NP_001193853 | MIM : 601020 | UniProt ID : P42081

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
ANGPTL3/Angiopoietin-like 3 Protein
PTGDS Protein
Popular categories:
IgG4
Complement Factor H Related 3

Share this post on:

Author: Cholesterol Absorption Inhibitors