Recombinant Human CDK5 Protein, His-tagged

Specification :
| Description : CDK5, also known as cyclin-dependent-like kinase 5 isoform 1, is a member of the cyclin dependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. This is activated by association with a neuron-specific activator, p35 or its isoform p39. CDK5 is probably involved in the control of the cell cycle. | Source : Insect cells | Species : Human | Tag : His | Predicted N Terminal : Met1 | Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. | Molecular Mass : 34.1kDa (298aa) 28-40KDa (SDS-PAGE under reducing conditions.) | Protein length : 1-292aa | AA Sequence : MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKYFDSCNGDLDP EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYSTSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN VVPKLNATGR DLLQNLLKCNPVQRISAEEA LQHPYFSDFC PPHHHHHH | Purity : > 90% by SDS – PAGE | Applications : SDS-PAGE | Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. | Concentration : 0.25 mg/ml (determined by Absorbance at 280nm) | Publication : A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes (2020) A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes (2023)