Active Recombinant Human CDK8 Protein, His-Tagged

Specification :
| Description : This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] | Source : Insect Cell | Species : Human | Tag : His | Form : Liquid | Bio-activity : 17 pmol/μg x min | Molecular Mass : CDK8: 83.051, CCNC: kDa | Applications : Functional StudySDS-PAGE | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing | Concentration : 0.433 μg/μL | Storage Buffer : In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 20% glycerol)