Active Recombinant Human CTLA4, HIgG1 Fc-tagged, mutant

Specification :
| Description : This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. | Source : CHO cells | Species : Human | Tag : HIgG1 Fc-tagged, mutant | Form : Lyophilized from 0.2μm-filtered solution in PBS. | Bio-activity : Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. | Molecular Mass : 39 KDa (monomer) | AA Sequence : Ala37-Ser160 | Endotoxin : | Purity : >98%, by SDS-PAGE under reducing conditions. | Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. | Reconstitution : Reconstitute at 100μg/ml in sterile PBS. | Warning : Avoid freeze/thaw cycles.