Recombinant Human CEACAM1 Protein, His-tagged

Specification :
| Description : This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. | Source : HEK293 | Species : Human | Tag : His | Form : Lyophilized | Molecular Mass : 44.2 kDa | Protein Length : 526 | AA Sequence : MGHLSAPLHRVRVPWQGLLLTASLL TFWNPPTTAQLTTESMPFNVAEGKE VLLLVHNLPQQLFGYSWYKGERVDG NRQIVGYAIGTQQATPGPANSGRET IYPNASLLIQNVTQNDTGFYTLQVI KSDLVNEEATGQFHVYPELPKPSIS SNNSNPVEDKDAVAFTCEPETQDTT YLWWINNQSLPVSPRLQLSNGNRTL TLLSVTRNDTGPYECEIQNPVSANR SDPVTLNVTYGPDTPTISPSDTYYR PGANLSLSCYAASNPPAQYSWLING TFQQSTQELFIPNITVNNSGSYTCH ANNSVTGCNRTTVKTIIVTELSPVV AKPQIKASKTTVTGDKDSVNLTCST NDTGISIRWFFKNQSLPSSERMKLS QGNTTLSINPVKREDAGTYWCEVFN PISKNQSDPIMLNVNYNALPQENGL SPGAIAGIVIGVVALVALIAVALAC FLHFGKTGRASDQRDLTEHKPSVSN HTQDHSNDPPNKMNEVTYSTLNFEA QQPTQPTSASPSLTATEIIYSEVKK Q | Purity : > 98% | Applications : WB; ELISA; FACS; FC | Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. | Storage : At -20 centigrade. | Concentration : 1 mg/mL | Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution. | Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.