Recombinant Human CLEC4A Protein, His-tagged

Specification :
| Description : C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca2+-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8+ T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8+ T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Source : E. coli | Species : Human | Tag : His | Molecular Mass : ~24 kDa | AA Sequence : MQKYSQLLEKKTTKELVHTTLECVK KNMPVEETAWSCCPKNWKSFSSNCY FISTESASWQDSEKDCARMEAHLLV INTQEEQDFIFQNLQEESAYFVGLS DPEGQRHWQWVDQTPYNESSTFWHP REPSDPNERCVVLNFRKSPKRWGWN DVNCLGPQRSVCEMMKIHL | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Storage Buffer : PBS, 4M Urea, pH7.4