Recombinant Human CSF1R protein, His-tagged

Specification :
| Description : The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. | Source : E. coli | Species : Human | Tag : His | Form : Freeze-dried powder | Molecular Mass : 20 kDa as determined by SDS-PAGE reducing conditions. | Protein length : Phe768~Ser928 (Accession # P07333) | Endotoxin : | Purity : >95% | Characteristic : The isoelectric point is 7.1. | Applications : SDS-PAGE; WB; ELISA; IP | Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. | Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. | Storage buffer : Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4. | Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.