Recombinant Human CTLA4 Protein (Met1-Asp161), C-His tagged

Specification :
| Description : CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. | Source : Mammalian cells | Species : Human | Tag : C-His | Form : Lyophilized powder/frozen liquid | Molecular Mass : 18.51 kDa | Protein Length : Met1-Asp161 | Endotoxin : | Purity : >90% as determined by SDS-PAGE. | Notes : For research use only. | Storage : Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. | Storage Buffer : Supplied as solution form in 150 mM NaCl, 50 mM Tris-HCl, pH 7.5 or lyophilized from 150 mM NaCl, 50 mM Tris-HCl, pH 7.5. | Reconstitution : Reconstitute in sterile water for a stock solution. | Shipping : They are shipped out with dry ice/blue ice unless customers require otherwise.