Recombinant Human DDR2 Protein, GST-tagged

Specification :
| Description : Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5′ UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 123.1 kDa | AA Sequence : MILIPRMLLVLFLLLPILSSAKAQV NPAICRYPLGMSGGQIPDEDITASS QWSESTAAKYGRLDSEEGDGAWCPE IPVEPDDLKEFLQIDLHTLHFITLV GTQGRHAGGHGIEFAPMYKINYSRD GTRWISWRNRHGKQVLDGNSNPYDI FLKDLEPPIVARFVRFIPVTDHSMN VCMRVELYGCVWLDGLVSYNAPAGQ QFVLPGGSIIYLNDSVYDGAVGYSM TEGLGQLTDGVSGLDDFTQTHEYHV WPGYDYVGWRNESATNGYIEIMFEF DRIRNFTTMKVHCNNMFAKGVKIFK EVQCYFRSEASEWEPNAISFPLVLD DVNPSARFVTVPLHHRMASAIKCQY HFADTWMMFSEITFQSDAAMYNNSE ALPTSPMAPTTYDPMLKVDDSNTRI LIGCLVAIIFILLAIIVIILWRQFW QKMLEKASRRMLDDEMTVSLSLPSD SSMFNNNRSSSPSEQGSNSTYDRIF PLRPDYQEPSRLIRKLPEFAPGEEE SGCSGVVKPVQPSGPEGVPHYAEAD IVNLQGVTGGNTYSVPAVTMDLLSG KDVAVEEFPRKLLTFKEKLGEGQFG EVHLCEVEGMEKFKDKDFALDVSAN QPVLVAVKMLRADANKNARNDFLKE IKIMSRLKDPNIIHLLAVCITDDPL CMITEYMENGDLNQFLSRHEPPNSS SSDVRTVSYTNLKFMATQIASGMKY LSSLNFVHRDLATRNCLVGKNYTIK IADFGMSRNLYSGDYYRIQGRAVLP IRWMSWESILLGKFTTASDVWAFGV TLWETFTFCQEQPYSQLSDEQVIEN TGEFFRDQGRQTYLPQPAICPDSVY KLMLSCWRRDTKNRPSFQEIHLLLL QQGDE | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.