Recombinant Human DMPK Protein, GST-tagged

Specification :
| Description : The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3′ untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016] | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 94.93 kDa | AA Sequence : MSAEVRLRRLQQLVLDPGFLGLEPL LDLLLGVHQELGASELAQDKYVADF LQWAEPIVVRLKEVRLQRDDFEILK VIGRGAFSEVAVVKMKQTGQVYAMK IMNKWDMLKRGEVSCFREERDVLVN GDRRWITQLHFAFQDENYLYLVMEY YVGGDLLTLLSKFGERIPAEMARFY LAEIVMAIDSVHRLGYVHRDIKPDN ILLDRCGHIRLADFGSCLKLRADGT VRSLVAVGTPDYLSPEILQAVGGGP GTGSYGPECDWWALGVFAYEMFYGQ TPFYADSTAETYGKIVHYKEHLSLP LVDEGVPEEARDFIQRLLCPPETRL GRGGAGDFRTHPFFFGLDWDGLRDS VPPFTPDFEGATDTCNFDLVEDGLT AMVSGGGETLSDIREGAPLGVHLPF VGYSYSCMALRDSEVPGPTPMELEA EQLLEPHVQAPSLEPSVSPQDETAE VAVPAAVPAAEAEAEVTLRELQEAL EEEVLTRQSLSREMEAIRTDNQNFA SQLREAEARNRDLEAHVRQLQERME LLQAEGATAVTGVPSPRATDPPSHL DGPPAVAVGQCPLVGPGPMHRRHLL LPARVPRPGLSEALSLLLFAVVLSR AAALGCIGLVAHAGQLTAVWRRPGA ARAP | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.