Recombinant Human ECD Protein, Myc/DDK-tagged, C13 and N15-labeled

Specification :
| Description : Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. | Source : HEK293 | Species : Human | Tag : Myc/DDK | Molecular Mass : 72.8 kDa | AA Sequence : MEETMKLATMEDTVEYCLFLIPDES RDSDKHKEILQKYIERIITRFAPML VPYIWQNQPFNLKYKPGKGGVPAHM FGVTKFGDNIEDEWFIVYVIKQITK EFPELVARIEDNDGEFLLIEAADFL PKWLDPENSTNRVFFCHGELCIIPA PRKSGAESWLPTTPPTIPQALNIIT AHSEKILASESIRAAVNRRIRGYPE KIQASLHRAHCFLPAGIVAVLKQRP RLVAAAVQAFYLRDPIDLRACRVFK TFLPETRIMTSVTFTKCLYAQLVQQ RFVPDRRSGYRLPPPSDPQYRAHEL GMKLAHGFEILCSKCSPHFSDCKKS LVTASPLWASFLESLKKNDYFKGLI EGSAQYRERLEMAENYFQLSVDWPE SSLAMSPGEEILTLLQTIPFDIEDL KKEAANLPPEDDDQWLDLSPDQLDQ LLQEAVGKKESESVSKEEKEQNYDL TEVSESMKAFISKVSTHKGAELPRE PSEAPITFDADSFLNYFDKILGPRP NESDSDDLDDEDFECLDSDDDLDFE THEPGEEASLKGTLDNLKSYMAQMD QELAHTCISKSFTTRNQVEPVSQTT DNNSDEEDSGTGESVMAPVDVDLNL VSNILESYSSQAGLAGPASNLLQSM GVQLPDNTDHRPTSKPTKNTRTRPL EQKLISEEDLAANDILDYKDDDDKV | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Stability : Stable for 3 months from receipt of products under proper storage and handling conditions. | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. | Concentration : 50 μg/mL as determined by BCA | Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.