Active Recombinant Human ERBB2 Protein, Fc Chimera | Cholesterol Absorption Inhibitors cholesterol-absorption.com

Name :
Active Recombinant Human ERBB2 Protein, Fc Chimera

Specification :
| Source : Mammalian cells | Species : Human | Tag : Fc | Predicted N Terminal : Thr23 | Form : Lyophilized from a 0.2 µm filtered solution in PBS. | Bio-activity : Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. Brodowicz, T. et al. (1997) Int. J. Cancer 73:875.The ED50 for this effect is typically 20-80 ng/mL in the presence of 0.6 µg/mL goat anti-hErbB2. | Molecular Mass : Recombinant Human ERBB2, Fc Chimera has a calculated MW of 96.8 kDa (monomer). In SDS-PAGE migrates as 125-130 kDa, reducing conditions220-250 kDa, non-reducing conditions. | Purity : >90%, by SDS-PAGE with silver staining. | Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information :
| Gene Name : ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ] | Official Symbol : ERBB2 | Synonyms : ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu; | Gene ID : 2064 | mRNA Refseq : NM_001005862 | Protein Refseq : NP_001005862 | MIM : 164870 | UniProt ID : P04626 | Chromosome Location : 17q11.2-q12

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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