Recombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged

Specification :
| Description : Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. | Source : E. coli | Species : Human | Tag : His-Myc | Form : Tris-based buffer,50% glycerol | Molecular Mass : 38.3 kDa | Protein length : 28-328 aa | AA Sequence : EVVLLDFAAAGGELGWLTHPYGKGW DLMQNIMNDMPIYMYSVCNVMSGDQ DNWLRTNWVYRGEAERIFIELKFTV RDCNSFPGGASSCKETFNLYYAESD LDYGTNFQKRLFTKIDTIAPDEITV SSDFEARHVKLNVEERSVGPLTRKG FYLAFQDIGACVALLSVRVYYKKCP ELLQGLAHFPETIAGSDAPSLATVA GTCVDHAVVPPGGEEPRMHCAVDGE WLVPIGQCLCQAGYEKVEDACQACS PGFFKFEASESPCLECPEHTLPSPE GATSCECEEGFFRAPQDPASMPCTR P | Purity : > 85% as determined by SDS-PAGE. | Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. | Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. | Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.