Recombinant Human ERBB2 protein, His-Avi-tagged

Specification :
| Description : ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. | Source : HEK293 | Species : Human | Tag : His-Avi | Form : Supplied as 0.22um filtered solution in PBS (pH 7.4). | Molecular Mass : The Protein has a calculated MW of 72.3kDa .As a result of glycosylation, the protein migrates as 80-100kDa based on Bis-Tris PAGE. | Protein length : It contains Thr 23 – Thr 652. | Endotoxin : Less than 0.05EU per ug by the LAL method. | Purity : > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC | Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. | Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.