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Name :
Active Recombinant Human FAS

Specification :
| Description : Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-Caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active Caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. | Source : E. coli | Species : Human | Form : Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. | Bio-activity : Fully biologically active when compared to standard. The ED50 determined by its ability to inhibit the cytotoxicity of Jurkat cells is less than 15 μg/ml, corresponding to a specific activity of >66.7 IU/mg, in the presence of 2ng/ml of rHuFas Ligand. | Molecular Mass : 17.6 kDa | AA Sequence : RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE CTLTSNTKCK EEGSRSN | Endotoxin : Less than 1EU/μg of rHusFasR/TNFRSF6 as determined by LAL method. | Purity : >95% by SDS-PAGE and HPLC analyses. | Usage : This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. | Storage : This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles. | Reconstitution : We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.

Gene Information :
| Gene Name : FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] | Official Symbol : FAS | Synonyms : FAS; Fas (TNF receptor superfamily, member 6); APT1, FAS1, TNFRSF6, tumor necrosis factor receptor superfamily, member 6; tumor necrosis factor receptor superfamily member 6; APO 1; CD95; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; APT1; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; | Gene ID : 355 | mRNA Refseq : NM_000043 | Protein Refseq : NP_000034 | MIM : 134637 | UniProt ID : P25445 | Chromosome Location : 10q24.1 | Pathway : Activation of Pro-Caspase 8, organism-specific biosystem; Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Alzheimers disease, organism-specific biosystem; | Function : binding; identical protein binding; kinase binding; protein binding; receptor activity; receptor activity; signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor-activated receptor activity;

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Author: Cholesterol Absorption Inhibitors