Recombinant Human ERBB2 Protein (Met1-Thr652), C-His tagged

Specification :
| Description : Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation. | Source : Mammalian cells | Species : Human | Tag : C-His | Form : Lyophilized powder/frozen liquid | Molecular Mass : 71.72 kDa | Protein Length : Met1-Thr652 | Endotoxin : | Purity : >90% as determined by SDS-PAGE. | Notes : For research use only. | Storage : Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. | Storage Buffer : Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. | Reconstitution : Reconstitute in sterile water for a stock solution. | Shipping : They are shipped out with dry ice/blue ice unless customers require otherwise.