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Name :
Recombinant Human ERN1 Protein, GST-tagged

Specification :
| Description : This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017] | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 33 kDa | AA Sequence : MPARRLLLLLTLLLPGLGVSDRGAW GGGQLATAGSGPGQRRGAGAGVRAG SATAAARCPVSPAVGGSGRA | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information :
| Gene Name : ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens ] | Official Symbol : ERN1 | Synonyms : ERN1; endoplasmic reticulum to nucleus signaling 1; ER to nucleus signalling 1; serine/threonine-protein kinase/endoribonuclease IRE1; inositol requiring enzyme 1; IRE1; IRE1P; ire1-alpha; inositol-requiring 1; inositol-requiring enzyme 1; inositol-requiring protein 1; protein kinase/endoribonuclease; endoplasmic reticulum-to-nucleus signaling 1; IRE1a; hIRE1p; FLJ30999; MGC163277; MGC163279; | Gene ID : 2081 | mRNA Refseq : NM_001433 | Protein Refseq : NP_001424 | MIM : 604033 | UniProt ID : O75460

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Author: Cholesterol Absorption Inhibitors