Recombinant Human F7 Protein, Myc/DDK-tagged, C13 and N15-labeled

Specification :
| Description : This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. | Source : HEK293 | Species : Human | Tag : Myc/DDK | Molecular Mass : 49.3 kDa | AA Sequence : MVSQALRLLCLLLGLQGCLAAVFVT QEEAHGVLHRRRRANAFLEELRPGS LERECKEEQCSFEEAREIFKDAERT KLFWISYSDGDQCASSPCQNGGSCK DQLQSYICFCLPAFEGRNCETHKDD QLICVNENGGCEQYCSDHTGTKRSC RCHEGYSLLADGVSCTPTVEYPCGK IPILEKRNASKPQGRIVGGKVCPKG ECPWQVLLLVNGAQLCGGTLINTIW VVSAAHCFDKIKNWRNLIAVLGEHD LSEHDGDEQSRRVAQVIIPSTYVPG TTNHDIALLRLHQPVVLTDHVVPLC LPERTFSERTLAFVRFSLVSGWGQL LDRGATALELMVLNVPRLMTQDCLQ QSRKVGDSPNITEYMFCAGYSDGSK DSCKGDSGGPHATHYRGTWYLTGIV SWGQGCATVGHFGVYTRVSQYIEWL QKLMRSEPRPGVLLRAPFPSGPTRT RPLEQKLISEEDLAANDILDYKDDD DKV | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Stability : Stable for 3 months from receipt of products under proper storage and handling conditions. | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. | Concentration : 50 μg/mL as determined by BCA | Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.