Recombinant Human Fas (TNF Receptor Superfamily, Member 6)

Specification :
| Cat. No. : FAS-4270H | Description : FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system. | Source : Human | Host : Escherichia Coli. | Form : 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME. | Purity : Greater than 95% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | Physical Appearance : Sterile liquid formulation. | Storage : CD95 although stable at 10°C for 5 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.