Recombinant Human Fas (TNF Receptor Superfamily, Member 6)

Specification :
| Cat. No. : FAS-1615H | Description : Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. | Source : Mammalian cells | Molecular Weight : The predicted molecular weight of Recombinant Human sFasR is 45 kDa. | State Of Matter : Lyophilized. | Purity : >97% by SDS Page and analyzed by silver stain. | Endotoxin : | Biological Activity : The biological activity of Human Soluble Fas Receptor is determined by its ability to inhibit the cytotoxicity of Jurkat cells. The expected ED50 for this effect is 10-15 mg/ml in the presence of 2 ng/ml of human FasL. | Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.