Recombinant Human FGFR1, Fc Chimera

Specification :
| Cat. No. : FGFR1-498H | Description : Fibroblast growth factors (FGFs) belong to a large family (23 human members) of mitogenic factors that range in molecular mass from 17-34kDa. FGFs exhibit high affinity for heparin and heparin like glycosaminoglycans (HLGAGs), and these interactions are required for signaling activation from the FGF receptors. | Source : Human 293 cells. | Amino Acid Sequence : RPSPTLPEQAQPWGAPVEVESFLVH PGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADS GLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKP NRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKE FKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLD VVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVN GSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNS IGLSHHSAWLTVLEALEGIPKVDKK VEPKSCDKTHTCPPCPAPELLGGPS VFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKT KPREEQYNSTYRVVSVLTVLHQDWL NGKEYKCRVSNKALPAPIEKTISKA KGQPREPQVYTLPPSRDELTKNQVS LTCLVKGFYPSDIAVEWESNGQPEN NYKTTPPVLDSDGSFFLYSKLTVDK SRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK. | Molecular Mass : FGF R1 alpha (IIIc)-Fc Chimera migrates as a broad band between 100 and 130 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. | pI : Due to post-translational modifications, in particular glycosylation, the Symansis FGF R1 alpha (IIIc)-Fc Chimera separates into multiple isoforms with a pI between 5.2 and 6.9 in 2D PAGE. | % Carbohydrate : Purified FGF R1 alpha (IIIc)-Fc Chimera consists of 35-50% carbohydrate (by wt). | Glycosylation : FGF R1 alpha (IIIc)-Fc Chimera has N-linked and probably O-linked oligosaccharides. | Purity : >95%, as determined by SDS-PAGE and visualized by silver stain. | Formulation : When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. | Storage : Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.