Recombinant Human FGFR1 Protein, GST-tagged

Specification :
| Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 108.3 kDa | AA Sequence : MWSWKCLLFWAVLVTATLCTARPSP TLPEQDALPSSEDDDDDDDSSSEEK ETDNTKPNPVAPYWTSPEKMEKKLH AVPAAKTVKFKCPSSGTPNPTLRWL KNGKEFKPDHRIGGYKVRYATWSII MDSVVPSDKGNYTCIVENEYGSINH TYQLDVVERSPHRPILQAGLPANKT VALGSNVEFMCKVYSDPQPHIQWLK HIEVNGSKIGPDNLPYVQILKTAGV NTTDKEMEVLHLRNVSFEDAGEYTC LAGNSIGLSHHSAWLTVLEALEERP AVMTSPLYLEIIIYCTGAFLISCMV GSVIVYKMKSGTKKSDFHSQMAVHK LAKSIPLRRQVTVSADSSASMNSGV LLVRPSRLSSSGTPMLAGVSEYELP EDPRWELPRDRLVLGKPLGEGCFGQ VVLAEAIGLDKDKPNRVTKVAVKML KSDATEKDLSDLISEMEMMKMIGKH KNIINLLGACTQDGPLYVIVEYASK GNLREYLQARRPPGLEYCYNPSHNP EEQLSSKDLVSCAYQVARGMEYLAS KKCIHRDLAARNVLVTEDNVMKIAD FGLARDIHHIDYYKKTTNGRLPVKW MAPEALFDRIYTHQSDVWSFGVLLW EIFTLGGSPYPGVPVEELFKLLKEG HRMDKPSNCTNELYMMMRDCWHAVP SQRPTFKQLVEDLDRIVALTSNQEY LDLSMPLDQYSPSFPDTRSSTCSSG EDSVFSHEPLPEEPCLPRHPAQLAN GGLKRR | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.