Recombinant Human FGFR1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Specification :
| Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. | Source : HEK293 | Species : Human | Tag : Myc/DDK | Molecular Mass : 89.4 kDa | AA Sequence : MWSWKCLLFWAVLVTATLCTARPSP TLPEQAQPWGAPVEVESFLVHPGDL LQLRCRLRDDVQSINWLRDGVQLAE SNRTRITGEEVEVQDSVPADSGLYA CVTSSPSGSDTTYFSVNVSDALPSS EDDDDDDDSSSEEKETDNTKPNRMP VAPYWTSPEKMEKKLHAVPAAKTVK FKCPSSGTPNPTLRWLKNGKEFKPD HRIGGYKVRYATWSIIMDSVVPSDK GNYTCIVENEYGSINHTYQLDVVER SPHRPILQAGLPANKTVALGSNVEF MCKVYSDPQPHIQWLKHIEVNGSKI GPDNLPYVQILKTAGVNTTDKEMEV LHLRNVSFEDAGEYTCLAGNSIGLS HHSAWLTVLEALEERPAVMTSPLYL EIIIYCTGAFLISCMVGSVIVYKMK SGTKKSDFHSQMAVHKLAKSIPLRR QVTVSADSSASMNSGVLLVRPSRLS SSGTPMLAGVSEYELPEDPRWELPR DRLVLGKPLGEGCFGQVVLAEAIGL DKDKPNRVTKVAVKMLKSDATEKDL SDLISEMEMMKMIGKHKNIINLLGA CTQDGPLYVIVEYASKGNLREYLQA RRPPGLEYCYNPSHNPEEQLSSKDL VSCAYQVARGMEYLASKKCIHRDLA ARNVLVTEDNVMKIADFGLARDIHH IDYYKKTTNGRLPVKWMAPEALFDR IYTHQSDVWSFGVLLWEIFTLGGSP YPGVPVEELFKLLKEGHRMDKPSNC TNELYMMMRDCWHAVPSQRPTFKQL VEDLDRIVALTSNQEYLDLSMPLDQ YSPSFPDTRSSTCSSGEDSVFSHEP LPEEPCLPRHPAQLANGGLKRRTRT RPLEQKLISEEDLAANDILDYKDDD DKV | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Stability : Stable for 3 months from receipt of products under proper storage and handling conditions. | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. | Concentration : 50 μg/mL as determined by BCA | Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.