Recombinant Human FGFR3 Protein

Specification :
| Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq | Source : Wheat Germ | Species : Human | Form : Liquid | Molecular Mass : 88.7 kDa | AA Sequence : MGAPACALALCVAVAIVAGASSESL GTEQRVVGRAAEVPGPEPGQQEQLV FGSGDAVELSCPPPGGGPMGPTVWV KDGTGLVPSERVLVGPQRLQVLNAS HEDSGAYSCRQRLTQRVLCHFSVRV TDAPSSGDDEDGEDEAEDTGVDTGA PYWTRPERMDKKLLAVPAANTVRFR CPAAGNPTPSISWLKNGREFRGEHR IGGIKLRHQQWSLVMESVVPSDRGN YTCVVENKFGSIRQTYTLDVLERSP HRPILQAGLPANQTAVLGSDVEFHC KVYSDAQPHIQWLKHVEVNGSKVGP DGTPYVTVLKTAGANTTDKELEVLS LHNVTFEDAGEYTCLAGNSIGFSHH SAWLVVLPAEEELVEADEAGSVYAG ILSYGVGFFLFILVVAAVTLCRLRS PPKKGLGSPTVHKISRFPLKRQVSL ESNASMSSNTPLVRIARLSSGEGPT LANVSELELPADPKWELSRARLTLG KPLGEGCFGQVVMAEAIGIDKDRAA KPVTVAVKMLKDDATDKDLSDLVSE MEMMKMIGKHKNIINLLGACTQGGP LYVLVEYAAKGNLREFLRARRPPGL DYSFDTCKPPEEQLTFKDLVSCAYQ VARGMEYLASQKCIHRDLAARNVLV TEDNVMKIADFGLARDVHNLDYYKK TTNGRLPVKWMAPEALFDRVYTHQS DVWSFGVLLWEIFTLGGSPYPGIPV EELFKLLKEGHRMDKPANCTHDLYM IMRECWHAAPSQRPTFKQLVEDLDR VLTVTSTDEYLDLSAPFEQYSPGGQ DTPSSSSSGDDSVFAHDLLPPAPPS SGGSRT | Applications : Antibody ProductionFunctional StudyCompound Screening | Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis. | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.