Recombinant Human FGFR3 Protein, DDK-tagged

Specification :
| Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. | Source : Insect cells | Species : Human | Tag : DDK | Form : 50mM Tris-HCl pH8.0, 100mM glycine, 10% glycerol. | Molecular Mass : 39 kDa | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. | Concentration : >50 ug/mL as determined by microplate BCA method