Recombinant Human FGFR3 Protein (ECD), Fc-His-tagged(C-ter)

Specification :
| Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017] | Source : HEK293 | Species : Human | Tag : Fc-His(C-ter) | Form : Powder | Protein Length : Glu23-Gly375 | Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test. | Purity : > 90% (by SDS-PAGE) | Applications : Binding, SDS-PAGE | Notes : For laboratory research only, not for drug, diagnostic or other use. | Storage : Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. | Storage Buffer : PBS (pH 7.4) | Reconstitution : Reconstitute to a concentration of 0.1-0.5 mg/ml in sterile distilled water.