Recombinant Human FGFR3 Protein, Fc-His-tagged

Specification :
| Description : This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. | Source : HEK293E cells | Species : Human | Tag : Fc-His | Form : Frozen / Solution | Molecular Mass : 66.4 kDa plus glycosylation. | Protein length : 1-372 | Applications : ELISA, Western Blot, Antibody Production, Protein array | Quality Control Test : 10% SDS-PAGE stained with Coomassie Blue (CB) and immunoblotted with monoclonal antibody against human FGFR3 (WB). | Storage : For extended storage, conserve at −80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. | Expiry : 12 months from the date of purchase, if it is properly stored. | Storage Buffer : 0.1M Glicina, 50mM Tris, pH 7.4. No preservatives added. | Shipping : Dry Ice