Recombinant Human FGFR3 protein, His-Avi-tagged, Biotinylated

Specification :
| Description : Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. | Source : HEK293 | Species : Human | Tag : His-Avi | Form : Supplied as 0.22μm filtered solution in PBS (pH 7.4). | Molecular Mass : The protein has a predicted MW of 41.1 KDa. Due to glycosylation, the protein migrates to 65-75 KDa based on Bis-Tris PAGE result. | Protein length : Glu23-Gly375 | Endotoxin : Less than 0.05EU per μg by the LAL method. | Purity : >95% as determined by Tris-Bis PAGE; >95% as determined by HPLC | Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.