Recombinant Human FGFR4 protein, hFc-tagged

Specification :
| Description : Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. | Source : HEK293 | Species : Human | Tag : hFc | Form : Supplied as 0. 22um filtered solution in PBS (pH 7. 4). | Molecular Mass : The protein has a predicted MW of 65. 3 kDa. Due to glycosylation, the protein migrates to 80- 95KDa based on Bis-Tris PAGE result. | Protein length : It contains Leu22-Asp369. | Endotoxin : Less than 0. 01EU per ug by the LAL method. | Purity : > 95% as determined by SDS-PAGE; > 95% as determined by HPLC | Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. | Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.