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Name :
Recombinant Human Fibroblast Growth Factor Receptor 3

Specification :
| Cat. No. : FGFR3-5003H | Description : Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. | Source : Human | Host : Insect cells | Form : Supplied as a lyophilized powder with no preservative. Reconstitute in sterile water to a concentration > 0.05mg/ml. | Purity : >90% pure by SDS PAGE | Molecular Mass : 170 kDa | Applications : Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions | Endotoxin Levels : | Storage : Store at -70 deg C until reconstitution. Following reconstitution product should be aliquoted and frozen at -20 deg C. Avoid repeated freeze/thaw cycles.

Gene Information :
| Gene Name : FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ] | Official Symbol : FGFR3 | Synonyms : FGFR3; fibroblast growth factor receptor 3; ACH; CEK2; JTK4; CD333; HSFGFR3EX; OTTHUMP00000149958; OTTHUMP00000149959; tyrosine kinase JTK4; hydroxyaryl-protein kinase; achondroplasia, thanatophoric dwarfism; EC 2.7.10.1; FGFR-3; CD333 antigen | Gene ID : 2261 | mRNA Refseq : NM_000142 | Protein Refseq : NP_000133 | MIM : 134934 | UniProt ID : P22607 | Chromosome Location : 4p16.3 | Pathway : Bladder cancer; Endocytosis; MAPK signaling pathway; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR | Function : ATP binding; fibroblast growth factor receptor activity; identical protein binding; nucleotide binding; receptor activity; transferase activity

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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Author: Cholesterol Absorption Inhibitors