Recombinant Human GP1BA Protein, GST-tagged

Specification :
| Description : Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 95.4 kDa | AA Sequence : MPLLLLLLLLPSPLHPHPICEVSKV ASHLEVNCDKRNLTALPPDLPKDTT ILHLSENLLYTFSLATLMPYTRLTQ LNLDRCELTKLQVDGTLPVLGTLDL SHNQLQSLPLLGQTLPALTVLDVSF NRLTSLPLGALRGLGELQELYLKGN ELKTLPPGLLTPTPKLEKLSLANNN LTELPAGLLNGLENLDTLLLQENSL YTIPKGFFGSHLLPFAFLHGNPWLC NCEILYFRRWLQDNAENVYVWKQGV DVKAMTSNVASVQCDNSDKFPVYKY PGKGCPTLGDEGDTDLYDYYPEEDT EGDKVRATRTVVKFPTKAHTTPWGL FYSWSTASLDSQMPSSLHPTQESTK EQTTFPPRWTPNFTLHMESITFSKT PKSTTEPTPSPTTSEPVPEPAPNMT TLEPTPSPTTPEPTSEPAPSPTTPE PTPIPTIATSPTILVSATSLITPKS TFLTTTKPVSLLESTKKTIPELDQP PKLRGVLQGHLESSRNDPFLHPDFC CLLPLGFYVLGLFWLLFASVVLILL LSWVGHVKPQALDSGQGAALTTATQ TTHLELQRGRQVTVPRAWLLFLRGS LPTFRSSLFLWVRPNGRLGPLVAGR RPSALSQGRGQDLLSTVSIRYSGHS L | Applications : Enzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. | Publication : Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions (2019)