Product Name :
NMS-P715
Description:
NMS-P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells.
CAS:
1202055-32-0
Molecular Weight:
676.73
Formula:
C35H39F3N8O3
Chemical Name:
N-(2,6-diethylphenyl)-1-methyl-8-(4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenylamino)-1H,4H,5H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Smiles :
CN1CCC(CC1)NC(=O)C1=CC(OC(F)(F)F)=C(C=C1)NC1=NC2C3=C(CCC=2C=N1)C(=NN3C)C(=O)NC1C(CC)=CC=CC=1CC
InChiKey:
JFOAJUGFHDCBJJ-UHFFFAOYSA-N
InChi :
InChI=1S/C35H39F3N8O3/c1-5-20-8-7-9-21(6-2)28(20)42-33(48)30-25-12-10-23-19-39-34(43-29(23)31(25)46(4)44-30)41-26-13-11-22(18-27(26)49-35(36,37)38)32(47)40-24-14-16-45(3)17-15-24/h7-9,11,13,18-19,24H,5-6,10,12,14-17H2,1-4H3,(H,40,47)(H,42,48)(H,39,41,43)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Papain site
Additional information:
NMS-P715 is a selective and orally bioavailable MPS1 inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells.Rilzabrutinib Protein Tyrosine Kinase/RTK |Product information|CAS Number: 1202055-32-0|Molecular Weight: 676.PMID:32914690 73|Formula: C35H39F3N8O3|Synonym:|NMS P715|NMS-P 715|Chemical Name: N-(2,6-diethylphenyl)-1-methyl-8-(4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenylamino)-1H,4H,5H-pyrazolo[4,3-h]quinazoline-3-carboxamide|Smiles: CN1CCC(CC1)NC(=O)C1=CC(OC(F)(F)F)=C(C=C1)NC1=NC2C3=C(CCC=2C=N1)C(=NN3C)C(=O)NC1C(CC)=CC=CC=1CC|InChiKey: JFOAJUGFHDCBJJ-UHFFFAOYSA-N|InChi: InChI=1S/C35H39F3N8O3/c1-5-20-8-7-9-21(6-2)28(20)42-33(48)30-25-12-10-23-19-39-34(43-29(23)31(25)46(4)44-30)41-26-13-11-22(18-27(26)49-35(36,37)38)32(47)40-24-14-16-45(3)17-15-24/h7-9,11,13,18-19,24H,5-6,10,12,14-17H2,1-4H3,(H,40,47)(H,42,48)(H,39,41,43)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
