Product Name :
PAO-Nap
Description:
PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
CAS:
1613402-20-2
Molecular Weight:
509.39
Formula:
C24H24AsN3O5
Chemical Name:
[4-(6-8-amino-2, 4-dioxo-3-azatricyclo[7.3.1.0, ]trideca-1(13), 5, 7, 9, 11-pentaen-3-ylhexanamido)phenyl]arsonous acid
Smiles :
NC1=CC=C2C3C1=CC=CC=3C(=O)N(CCCCCC(=O)NC1C=CC(=CC=1)[As](O)O)C2=O
InChiKey:
CVWSXPBPPSJPCI-UHFFFAOYSA-N
InChi :
InChI=1S/C24H24AsN3O5/c26-20-13-12-19-22-17(20)5-4-6-18(22)23(30)28(24(19)31)14-3-1-2-7-21(29)27-16-10-8-15(9-11-16)25(32)33/h4-6,8-13,32-33H,1-3,7,14,26H2,(H,27,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker.ATPA Immunology/Inflammation PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.ISO-1 site |Product information|CAS Number: 1613402-20-2|Molecular Weight: 509.PMID:32930061 39|Formula: C24H24AsN3O5|Chemical Name: [4-(6-8-amino-2, 4-dioxo-3-azatricyclo[7.3.1.0, ]trideca-1(13), 5, 7, 9, 11-pentaen-3-ylhexanamido)phenyl]arsonous acid|Smiles: NC1=CC=C2C3C1=CC=CC=3C(=O)N(CCCCCC(=O)NC1C=CC(=CC=1)[As](O)O)C2=O|InChiKey: CVWSXPBPPSJPCI-UHFFFAOYSA-N|InChi: InChI=1S/C24H24AsN3O5/c26-20-13-12-19-22-17(20)5-4-6-18(22)23(30)28(24(19)31)14-3-1-2-7-21(29)27-16-10-8-15(9-11-16)25(32)33/h4-6,8-13,32-33H,1-3,7,14,26H2,(H,27,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h).|References:|Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.Products are for research use only. Not for human use.|
