Recombinant Human HORMAD2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Specification :
| Description : Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. | Source : HEK293 | Species : Human | Tag : Myc/DDK | Molecular Mass : 35.3 kDa | AA Sequence : MATAQLSHCITIHKASKETVFPSQI TNEHESLKMVKKLFATSISCITYLR GLFPESSYGERHLDDLSLKILREDK KCPGSLHIIRWIQGCFDALEKRYLR MAVLTLYTDPMGSEKVTEMYQFKFK YTKEGATMDFDSHSSSTSFESGTNN EDIKKASVLLIRKLYILMQDLEPLP NNVVLTMKLHYYNAVTPHDYQPLGF KEGVNSHFLLFDKEPINVQVGFVST GFHSMKVKVMTEATKVIDLENNLFR ENSTTEIAHQGLDCDEEEECNDHIQ RMNFVCSQQSSECSRKKRKVSEPVK VFIPNRKTRTRPLEQKLISEEDLAA NDILDYKDDDDKV | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Stability : Stable for 3 months from receipt of products under proper storage and handling conditions. | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. | Concentration : 50 μg/mL as determined by BCA | Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.