Recombinant Human ICAM2 Protein, His-tagged

Specification :
| Description : Intercellular cell adhesion molecule-2 (CD102/ICAM-2) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. Like CD54/ICAM-1, CD102/ICAM-2 is a ligand that binds the leukocyte adhesion molecule LFA-1 (leukocyte function-associated antigen-1), which mediates intercellular interactions between immune cells and other cell types. Expression of CD102/ICAM-2 has been shown to affect angiogenesis, cellular radioresistance and anti-tumor immune response. Along with CD54/ICAM-1, CD102/ICAM-2 mediates T cell crawling and diapedesis across the blood-brain barrier, as well as T cell migration across the bronchial epithelium. CD102/ICAM-2 interaction with the actin cytoskeleton through α-actinin has been shown to limit the mobility on neuroblastoma cells, and this effect is dependent on glycosylation of CD102/ICAM-2. | Source : E. coli | Species : Human | Tag : His | Molecular Mass : ~30 kDa | AA Sequence : KVFEVHVRPKKLAVEPKGSLEVNCS TTCNQPEVGGLETSLDKILLDEQAQ WKHYLVSNISHDTVLQCHFTCSGKQ ESMNSNVSVYQPPRQVILTLQPTLV AVGKSFTIECRVPTVEPLDSLTLFL FRGNETLHYETFGKAAPAPQEATAT FNSTADREDGHRNFSCLAVLDLMSR GGNIFHKHSAPKMLEIYEPVSDSQ | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Storage Buffer : PBS, 4M Urea, pH7.4