Recombinant Human ICOS Protein, Gly/Pro-tagged, Alexa Fluor 488 conjugated

Specification :
| Description : Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2–CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness. | Source : HEK293 | Species : Human | Tag : Gly/Pro | Form : Lyophilized | Protein length : Met1-Phe141 | N-terminal Sequence Analysis : Glu 21 | Endotoxin : | Purity : > 94 % as determined by SDS-PAGE | Characteristic : Disulfide-linked homodimerLabeled with Alexa Fluor 488 via aminesExcitation Wavelength: 488 nmEmission Wavelength: 515­-545 nm | Stability : Samples are stable for up to 12 months from date of receipt at -70 centigrade. | Storage : Store it under sterile conditions at -20 centigradeto -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. | Storage Buffer : Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. | Shipping : Shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.