Product Name :
KJ Pyr 9
Description:
KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay.
CAS:
581073-80-5
Molecular Weight:
385.37
Formula:
C22H15N3O4
Chemical Name:
4-[2-(furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl]benzamide
Smiles :
NC(=O)C1C=CC(=CC=1)C1=CC(=NC(=C1)C1C=CC(=CC=1)[N+]([O-])=O)C1=CC=CO1
InChiKey:
GTTDVYCKFQYVNN-UHFFFAOYSA-N
InChi :
InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay.|Product information|CAS Number: 581073-80-5|Molecular Weight: 385.37|Formula: C22H15N3O4|Chemical Name: 4-[2-(furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl]benzamide|Smiles: NC(=O)C1C=CC(=CC=1)C1=CC(=NC(=C1)C1C=CC(=CC=1)[N+]([O-])=O)C1=CC=CO1|InChiKey: GTTDVYCKFQYVNN-UHFFFAOYSA-N|InChi: InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (648.73 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|KJ Pyr 9 (KJ-Pyr-9) interferes with MYC-MAX complex formation in the cell, as shown in a protein fragment complementation assay. KJ Pyr 9 specifically inhibits MYC-induced oncogenic transformation in cell culture; it has no or only weak effects on the oncogenic activity of several unrelated oncoproteins. KJ Pyr 9 preferentially interferes with the proliferation of MYC-overexpressing human and avian cells and specifically reduces the MYC-driven transcriptional signature.Griseofulvin Apoptosis KJ Pyr 9 against three cell lines is tested known to be dependent on increased MYC activity: NCI-H460, MDA-MB-231, and SUM-159PT.Fitusiran manufacturer The proliferation of all cell lines tested is inhibited, with IC50 values between 5 and 10 μM.PMID:32529856 Additionally, the proliferation of Burkitt lymphoma cell lines, which show constitutively high expression of c-MYC, is more sensitive to KJ Pyr 9 (IC50 values between 1 and 2.5 μM).|In Vivo:|To test the in vivo effectiveness of KJ Pyr 9 (KJ-Pyr-9), nude mice receive a xenograft of MDA-MB-231 cells suspended in Matrigel and injected s.c. into the left and right flanks. When the tumors have reached an average volume of 100 mm3, mice are treated daily with 10 mg/kg KJ Pyr 9 or vehicle control by i.p. injection for 31 d. Inhibition of tumor growth by KJ Pyr 9 is noted after 8 d of treatment. By day 31, the tumor volume in the KJ Pyr 9-treated animals has not increased significantly. At the conclusion of the experiment the tumors are extracted and weighed. The weight measurements are in agreement with the volume determinations and confirmed the ability of KJ Pyr 9 to halt tumor growth.|Products are for research use only. Not for human use.|
