Product Name :
Rabbit anti-CD99 Polyclonal Antibody
Synonym :
12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2
Host :
Rabbit
Species Reactivity:
Human
Specificity :
CD99 Antibody detects endogenous levels of total CD99.
Predicted Reactivity:
Applications :
WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen:
A synthesized peptide derived from Human CD99(Accession P14209), corresponding to amino acid residues D61-S89.
Concentration :
1mg/ml
Purification :
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality:
Monoclonal Antibody
Storage Temp.:
Store at -20 ° C for one yearAvoid repeated freeze/that cycles
Research areas :
Background :
CD99 is cell surface protein expressed on multiple diferent cell types, including lymphocytes, that is involved in a range of cellular processes including cellular adhesion and migration, apoptosis and cell survival, T-cell diferentiation, and cancer biology [PMID: 29305692, PMID: 29534016]. Moreover, CD99 is ofen expressed on myeloid and lymphoid leukemia cells and can both aid in leukemia diagnosis and correlate with prognosis [PMID: 27764235, PMID: 21487112, PMID: 30484860].
UniProt :
P14209
Additional information:
Product Details FAQ Citations(1) Video Pictures Documents |Overview |Description The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |Synonym 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2 |Host Rabbit |Specificity CD99 Antibody detects endogenous levels of total CD99. |Species Reactivity Human |Applications WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000 |Immunogen A synthesized peptide derived from Human CD99(Accession P14209), corresponding to amino acid residues D61-S89. |Properties |Form Liquid |Concentration 1mg/ml |Purification The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |Clonality Monoclonal Antibody |Clone R122 |Storage Temp. Store at -20 ° C for one yearAvoid repeated freeze/that cycles |Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |Target |Background CD99 is cell surface protein expressed on multiple diferent cell types, including lymphocytes, that is involved in a range of cellular processes including cellular adhesion and migration, apoptosis and cell survival, T-cell diferentiation, and cancer biology [PMID: 29305692, PMID: 29534016]. Moreover, CD99 is ofen expressed on myeloid and lymphoid leukemia cells and can both aid in leukemia diagnosis and correlate with prognosis [PMID: 27764235, PMID: 21487112, PMID: 30484860]. |Post-translational modifications Extensively O-glycosylated. |Cellular localization Plasma Membrane; |UniProt P14209 | Western blot analysis of extracts of variouscell lines, using CD99 antibody. |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-CD99 Recombinant Monoclonal Antibody(R122)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
1613695-14-9 Technical Information 13411-16-0 Protocol PMID:30725879 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
