Name :
Recombinant Human IGF1R
Specification :
| Description : This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. | Biological activity : Specific activity: ~100 nmol/min/mg at 25°C using poly(Glu:Tyr)4:1 substrate.Reaction conditions are 50 mM Tris, pH 7.5, 5 mM MgCl2, 5 mM MnCl2, 1 mM DTT, 250 μM ATP. The kinase concentration was 0.5-1 μM and poly-L-lysine was added in equimolar amounts t | Form : Liquid | Storage buffer : Preservative: NoneConstituents: 50mM Tris, 1mM DTT, pH 7.5 | Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Gene Information :
| Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] | Official Symbol : IGF1R | Synonyms : IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; | Gene ID : 3480 | mRNA Refseq : NM_000875 | Protein Refseq : NP_000866 | MIM : 147370 | Uniprot ID : P08069 | Chromosome Location : 15q26.3 | Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; | Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding;
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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