D B cells exhibit drastically longer telomeres and elevated telomerase activity (12). The present study aimed to investigate the cytotoxic mechanisms of CAUE in NALM-6 cells and, as shown in Fig. 1, CAUE exhibited preferential harm to DNA synthesis compared with RNA and protein synthesis. This indicated that CAUE directly affects the nucleus and impairs DNA synthesis, resulting within the induction of apoptosis. Caffeic acid phenethyl ester is a parent compound of CAUE and a single of its pharmacological mechanisms of DNA damage entails the NPY Y4 receptor Agonist Storage & Stability inhibition of nuclear element B (NF- B) (13). Caffeic acid derivatives block NF- B activation (7), and it has been hypothesized that NF- B inhibitory molecules are clinically helpful as single therapeutic agents or in mixture with RSK3 Inhibitor Purity & Documentation classical chemotherapeutic agents for the treatment of hematological malignancies (14). Consequently, CAUE could inhibit NF- B in leukemia cells and damage DNA to trigger the induction of apoptosis. NF- B regulates hTERT expression by binding to a internet site 350-bp upstream of the translational initiation site (15). Furthermore, it has been reported that telomerase straight regulates NF- B-dependent genes in cancer cells (16). Thus, there is a close correlation amongst NF- B and telomerase activity. The outcomes with the present study indicate that CAUE inhibits telomerase activation by way of mediation of hTERT protein expression, consequently, we hypothesize that the inhibition by CAUE is dependent on the inhibition of NF- B activation.In conclusion, CAUE inhibits DNA synthesis and suppresses telomerase activity. Targeting the inhibition of telomerase has been hypothesized to be advantageous for cancer chemotherapy as a consequence of its selectivity against malignant cells, thereby reducing side-effects. Telomerase inhibition is likely to become tested on humans in the future, in order to treat lymphoid cancers, such as B-cell leukemia (17). The observations from the present study might therefore help the development of therapeutic approaches for leukemia sufferers.
Open Access Case ReportLaparoscopic removal of an intrauterine device from the sigmoid colonFatih anlikan1, Ouz Arslan2, Muhittin Eftal Avci3, Ahmet G men4 ABSTRACT Uterine wall perforation which is frequently seen through the posterior wall in the uterus would be the most seriouscomplicationofanintrauterinedevice(IUD).WepresentacaseoflaparoscopicremovalofanIUD fromthesigmoidcolonina31-years-oldfemalewhowasadmittedtohospitalwithahistoryofpelvicpain andabnormalvaginalbleedingforonemonth.ThedislocatedIUDwasremovedfromthesigmoidcolonof laparoscopicinterventionwithoutanycomplications. In conclusion, the treatment modality for the removal of a dislocated IUD is feasible by laparoscopic surgeryinselectedpatientswherethedislocatedIUDisaccessible. Key WORDS: Dislocatedintrauterinedevice,Laparoscopicsurgery.doi: dx.doi.org/10.12669/pjms.311.How to cite this:anlikan F, Arslan O, Avci ME, G males A. Laparoscopic removal of an intrauterine device in the sigmoid colon. Pak J Med Sci 2015;31(1):214-216. doi: dx.doi.org/10.12669/pjms.311.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(creativecommons.org/licenses/by/3.0), whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.INTRODUCTION The usage of an intrauterine device as a contraceptive process is extremely popular within the planet, particularly in building countries. In Turkey, where the fertility rates are slightly greater than the world.
