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Drugs targeting signaling pathways involved in cancer pathogenesis play an growing role in cancer therapy. These agents differ from traditional cytotoxic chemotherapy not just in mechanism of action but additionally with regard to toxicity profile. Importantly, every single new class of “targeted” therapeutic is usually related having a one of a kind side effect profile connected to both ontarget and off-target effects. One such novel class of “targeted” anticancer agents is definitely the inhibitors of the mammalian target of rapamycin (mTOR). The mTOR pathway is important to quite a few oncogenic processes which include cell survival, cell development, and tumor angiogenesis [1]. Inhibiting this pathway with mTOR inhibitors or rapalogs has demonstrated anticancer effects across a wide variety of tumor kinds. At the moment, two mTOR inhibitors have received regulatory approval from.
