Ccur within the lung parenchyma primarily in patients with severe acute respiratory distress syndrome (ARDS) [4]. We describe the case of a spontaneously breathing patient with mild SARS-CoV-2 illness confirmed by realtime polymerase chain reaction (RT-PCR) that presented towards the emergency division (ED) with hydropneumothorax.Case PresentationA 23-year-old Caucasian patient with no medical history presented for the emergency division (ED) complaining of fever immediately after getting in contact having a COVID-19 good patient. His medical history revealed an influenza-like syndrome starting five days ago with a fever as much as 38.six , dry cough, and headache. On admission, the patient was alert, with a respiratory price of 22 breaths/min, pulse oximetry at 98 on room air, heart price at 78 beats per minute, and blood pressure at 118/63 mmHg, with no evidence of appropriate or left heart failure.IL-18 Protein Synonyms Lung auscultation identified diminished lung sounds in the right hemithorax.CD59 Protein Synonyms Blood gas analysis revealed pH: 7.43, PaO2: 79 mmHg, and PaCO2: 39 mmHg. On basic examination, no lymphadenopathy was observed, and also other systems, which includes cardiac and abdominal examination, were regular. Lab tests have been unremarkable. Nasopharyngeal swab RT-PCR testing for COVID-19 was positive (cycle threshold: 19). An upright chest x-ray showed an air-fluid level within the ideal hemithorax (Figure 1). Chest computed tomography showed a collapse of the appropriate lung, a sizable effusion, and pneumothorax (Figure two) with normal lung parenchyma. No ground glass opacities, consolidations, bronchopleural fistula, pneumomediastinum, or subcutaneous emphysema were observed.How you can cite this short article Pantazopoulos I N, Pagonis A, Perlepe G, et al. (February 12, 2022) Hydropneumothorax With Persistent Air Leak in a Patient With Mild COVID-19 Disease.PMID:30125989 Cureus 14(2): e22150. DOI 10.7759/cureus.FIGURE 1: Initial chest x-ray showing air fluid level within the ideal thoracic cavity (white arrows)FIGURE 2: Chest computed tomography showing a big right-sided hydropneumothoraxThe patient was admitted towards the pulmonology ward after a chest tube was inserted around the right hemithorax, draining a semi-clear, yellow fluid and air. The chest tube was initially placed on -20 cm H2O suction. Pleural fluid was sent for cell count, biochemistry, cytology, acid quick bacilli staining, and Gram-stain, culture, and sensitivity. Diagnostic pleural analysis revealed an exudative effusion with pleural fluid Ph of 7.31, the glucose of 1 mg/dL, and really higher lactate dehydrogenase (LDH) of 1381 U/L. The pleural fluid differential white blood cell count had 20 lymphocytes, 32 neutrophils, 48 atypical mononuclear cells with cytology damaging for2022 Pantazopoulos et al. Cureus 14(2): e22150. DOI ten.7759/cureus.2 ofmalignant cells. Adenosine deaminase from the pleural fluid was 128 IU/L. Pleural fluid stains and culture had been adverse for bacteria and tuberculosis. Routine screening tests for connective-tissue illness had been also adverse. The interferon-gamma release assay (IGRA) for tuberculosis (TB) outcome was adverse. SARS-Cov-2 performed by RT-PCR (Direct SARS-CoV-2 Real-Time PCR kit, Vircell, Granada, Spain) was not detected in pleural fluid. The patient was maintained on antibiotics (ceftriaxone), and analgesia (paracetamol). Both the effusion and air persisted for ten days (Figure three) as well as the patient was transferred to the department of thoracic surgery. Three days later as a result of persistent air leak, the patient was treated surgically with video-a.